Brazilian scientists intend to use artificial intelligence to detect COVID-19 through coughing
News

Brazilian scientists intend to use artificial intelligence to detect COVID-19 through coughing

Scientists at the Butantan Institute and Fiocruz want to train the use of artificial intelligence in the diagnosis of the disease and other lung conditions. The idea of such a program is to detect sound peculiarities that could be indicative of diseases.

The research began this week and its first phase consists of volunteers sending coughing audios. With this, the database obtained will assist in the training of artificial intelligence, which was developed by Intel.

Initially, the goal is to obtain 900 audios, of which 300 of them coming from healthy people, 300 from people diagnosed by Covid-19 by exams, and 300 with other lung diseases. Among healthy people, researchers want to force coughs from people who have had no symptoms of cough, fever, or shortness of breath in the past 30 days.

Participants with Covid-19 must be confirmed by molecular testing (PCR). In this case, the researchers will also collect data such as age, symptom days, respiratory rate, oxygen saturation, among others.

Finally, for the group of people who cough without Covid-19, researchers look for diseases such as bacterial pneumonia, gastroesophageal reflux, asthma, or Chronic Obstructive Pulmonary Disease (COPD).

Only people over 18 can “donate” the cough, which should be done on SoundCov. On the website, the participant must record coughing audio (30 to 60 seconds) and then answer a questionnaire. The data collected by the survey is anonymous.

The public-private partnership was intermediated by the Competitive Brazil Movement (MBC), and also has participation from USP (University of São Paulo) and UFMS (the Federal University of Mato Grosso do Sul).

News from: Diário de Pernambuco

Brazilian scientists discover super therapy to cure AIDS
News

Brazilian scientists discover super therapy to cure AIDS

A survey conducted by the Federal University of São Paulo (Unifesp) showed that the cure for acquired immunodeficiency syndrome (AIDS) is near. This is the first study, on a global scale, to test overtreatment in individuals chronically infected with the human immunodeficiency virus (HIV).

The coordinator of the research is the infectologist Ricardo Sobhie Diaz. Together with his team, Diaz has been working on two fronts to cure the disease. One uses drugs and substances that kill the virus at the time of replication and eliminate the cells where HIV is asleep (latency); the other develops a vaccine that causes the immune system to react and eliminate infected cells that the drug is unable to reach.

The research was carried out with 30 volunteers with an undetectable viral load, under standard treatment, according to what is currently recommended: the combination of three types of antiretrovirals, better known as “cocktail”. The volunteers were divided into six subgroups, each receiving different combinations of medicines, in addition to the “cocktail” itself.

For members of the subgroup that had the best results so far, two more antiretrovirals were administered: Dolutegravir, the strongest drug currently available on the market; and Maraviroc, a substance that forces the virus, previously hidden, to appear.

News from: Exame

notícia
News

Remdesivir is approved for testing on coronavirus patients in Brazil and Europe

Brazil can already start testing with remdesivir, an antiviral medication, in the treatment of patients with COVID-19, according to a statement made by the Brazilian Health Regulatory Agency (Anvisa) on Wednesday (25).

Anvisa also announced that the study to be carried out in the country will be phase 3, which involves the observation of patients who are being treated with the drug. People who are already hospitalized with severe pneumonia caused by the new coronavirus will receive the drug, divided into two groups.

The first will be treated with remdesivir combined with another medication called tocilizumab, which acts in the body as an immunoregulator and is used against rheumatoid arthritis. The second group will receive remdesivir given with a placebo. The idea is that in Brazil, according to authorization requested by the company PPD do Brasil Suporte a Pesquisa Clínica Ltda, 105 patients pass the test.

Approval in Europe

Remdesivir has also received approval from the European Medicines Agency (EMA), which can now be prescribed for patients diagnosed with COVID-19, requiring mechanical breathing, and who are 12 years of age or older. It is up to the European Commission to finalize the authorization in a bureaucratic manner, which should happen within a week. Once approved, the indication of the drug will be in force in 27 countries and will be valid for one year.

As there is still no proof that the drug is really effective against COVID-19, the North American pharmaceutical manufacturer Gilead needs to inform the European Union of the results of the remdesivir tests, as well as their side effects, by December.

What is Remdesivir for?

Remdesivir is an antiviral developed to combat Ebola, but which has already shown positive results in the treatment of other types of coronavirus, responsible for SARS and MERS diseases. In the United States, the drug has already been approved for serious patients in COVID-19, shortly after authorization by the regulatory agency Food and Drug Administration (FDA).

According to the FDA, the criterion used to approve the drug was a study by the American National Institute of Health (NIH), which conducted tests on 1,063 patients not only in the United States, but in Asia and Europe. The result showed that people treated with remdesivir recovered about four days before those who did not receive the drug. In early June, South Korea and India also began testing the drug.

News from: Canal Tech

rio de janeiro
News

Madrid Protocol and Brazilian culture

The accession of Brazil to the Madrid Protocol, in October 2019, brought not only a new way of protecting trademarks for Brazilian businessmen abroad, but also significant changes for those professionals working in the area of trademarks as well as challenges. One of these challenges is the translation of the names of various ingredients from the cuisine, drinks, typical dishes, musical instruments, and artistic expressions into English or Spanish, languages adopted by Brazil for the use of the Madrid Protocol. Not infrequently, what is expressed in the source language in a single term needs to be translated into a sentence in order to be understood.

Typical Brazilian products and services are included in the WIPO classifier

A beautiful initiative by members of the Brazilian Patent Office’s (BPTO) Products and Services Classification Commission (CCPS), together with the World Intellectual Property Organization (WIPO), resulted in the formulation of a robust list of typically Brazilian products and services and their inclusion in the classification nomenclatures of this entity, in the so-called Madrid Goods and Services Manager (MGS), with the respective translation. There are 668 descriptions of the most varied fruits, dishes, drinks, and services typically Brazilian.

According to information on the BPTO’s own website, the elaboration of this list aims to prevent offices in other countries from granting protection as a trademark for designations that are actually descriptive of the product or service itself. This study took into account the fact that not only Brazilian legislation, but also that of the vast majority of countries prohibit registration as a trademark of descriptive and/or generic terms in relation to the products or services of interest.

In addition, it is necessary to pay attention to the principle of the veracity of trademark preaches. By virtue of this principle, a trademark cannot be misleading, that is, it cannot mislead the consumer or in an improper association as to origin, composition, place of production, among other factors.

The compilation of these product and service descriptions and their inclusion in the Madrid Goods and Services Manager (MGS) with the English language equivalent can be considered an important milestone and a commendable effort, not only for the reasons already explained but also for corroborating aspects of our culture and tradition.

News from: ConJur

News

BPTO and CAS establish technical cooperation agreement to strengthen fight against patent backlog

According to a publication in the Official Gazette this Wednesday (06/10/2020), BPTO and CAS, a non-profit division of the American Chemical Society, signed a technical cooperation agreement to expedite the examination of patents. The agreement establishes BPTO’s participation in a CAS Search Report pilot, with the aim of improving the patent workflow at the Institute.

The technology, which will be tested and optimized, is able to assess similarities with the state of the art from parameters of a patent application important for the examiner’s analysis. In addition, the system combines machine learning and data selected by humans, which improves the results offered.

News from: BPTO

News

Dispute over the use of iPhone trademark in Brazil reaches the Federal Supreme Court (STF)

The episode for the rights of exclusive use over the iPhone trademark in Brazil has begun a new chapter this week. After losing in different courts to Apple, IGB Eletrônica, formerly Gradiente, took the case to be tried by the Federal Supreme Court (STF).

Both companies have been fighting in the courts since the beginning of the decade. The Brazilian company registered the term iPhone (with a capital I) in 2000 at the Brazilian Patent and Trademark Office (BPTO). It took the agency eight years to grant the registration. At that time, Apple had launched its own iPhone in 2007.

In 2012, Gradiente then launched a line of smartphones with its trademark. Equipped with the Android operating system, the devices have nothing to do with Apple’s phone. In 2014, the pre-sale of the iPhone C-600 model even made the IGB’s shares rise. Sales, however, sank.

IGB’s new action against Apple refers to an Extraordinary Appeal (ARE 1266095), which is the impugnation before the Federal Supreme Court against a judicial decision issued by a State or Federal court. In this case, the Superior Court of Justice (STJ).

In 2018, Gradiente lost the battle in the STJ court to Apple. In the decision, it was determined that both companies could use the term.

The Judge-Rapporteur, Minister Luís Felipe Salomão, argued at the time that “the use of the ‘iPhone’ trademark by Apple does not show any circumstance that implies, even potentially, parasitic exploitation, diversion of customers or dilution of the trademark, with the induction of consumers in mistake”.

The minister also made it clear that “such exegesis does not prejudice the IGB, which, having previously registered the expression ‘G GRADIENTE IPHONE’, may continue to use it, but ruling out only the exclusivity of using the expression ‘iPhone’ in isolation ”.

Filed on April 24, 2020, the appeal cites IGB Eletrônica as part of the process, as an appellant; Apple, as a defendant; in addition to the BPTO. There is no prediction as to when the appeal will be tried at the Supreme Court.

News from: Exame

News

IBM releases free use of patents to fight coronavirus

Owner of one of the largest patent holdings on the planet, IBM announced the release of its entire portfolio for free use in the development of technologies that help in the diagnosis, prevention, containment, or treatment of the new coronavirus. The measure includes ownership records in fields such as artificial intelligence, where the company is one of the global leaders with Watson, and even in the area of ​​biological viruses.

According to the company, the commitment encompasses more than 80 thousand patents and applications already registered, in addition to any new application submitted until the end of 2023. Researchers, companies and institutions interested in reviewing the available patents can search the public databases of The United States Patent and Trademark Office.

“To commit to not claiming patents from entities that use them in the fight against coronavirus, IBM is joining the Open Covid Pledge, which invites organizations to make their intellectual property available for free to use to combat the pandemic and to minimize the impact of disease”, Mark Ringes, legal counsel for IBM, said in a statement.

Among the patents made available free by IBM are those for artificial intelligence, including the technologies behind IBM Watson. The system became known worldwide at the beginning of the decade, after beating human competitors on an American question-and-answer TV show. Today, Watson offers several cloud services.

But in addition to the technology field, the company has a patent that describes antiviral agents, including molecules with activity against a broad spectrum of viruses, such as dengue, H1N1 and coronavirus. Another patent describes a touchscreen that uses ultraviolet light for disinfection. There are also algorithms that predict the duration and scope of events, including epidemics.

News from: O Globo

News

BPTO will accelerate examination of patents related to combating Covid-19

With a focus on stimulating the production and licensing of new technologies, BPTO will prioritize examining patent applications for innovations that can be used to combat the new coronavirus pandemic. The measure was made official through Ordinance No. 149/2020, published on April 7.

The prioritization is valid until 06/30/2021, as determined by Ordinance No. 149/2020.

The granting of a patent by BPTO attests that its object is new and guarantees the holder the exclusivity for use and licensing in Brazil (the patent has national validity). Therefore, with a patent granted, inventors gain more security to start production or license to a partner who can produce it.

Among the modalities of priority patent application, one of them is focused on health technologies, especially those strategic for the Unified Health System (SUS). Now, technologies related to combating the new coronavirus become part of this accelerated examination.

Technologies Observatory

Still in the context of the pandemic, INPI created, in March, the Observatory of Technologies Related to Covid-19. The objective is to disseminate technologies that can contribute to coping with the situation, including vaccines, medications, diagnostic tests, masks, and health equipment. Initiatives on funding and incentives for research in this area are also being disseminated.

Among the recent updates, the Observatory presents a study on patents filed with BPTO regarding diagnostic methods for Covid-19 and other respiratory viruses.

In this way, the relevant information is contributed to public agents and members of the National Innovation System who are directly linked to fighting the disease. For more information, visit the Observatory.

 

News from: BPTO

News

MSF calls for patents not to be created on treatments and vaccines against the new coronavirus

The international humanitarian organization Médecins Sans Frontières (MSF) this weekend called for no patents to be granted and no speculation about drugs, tests or vaccines developed to combat the Covid-19 pandemic caused by the new coronavirus. They also asked governments to prepare to suspend and replace patents and take other measures, such as price controls, to ensure availability, reduce prices and save more lives.

Canada, Chile, Ecuador and Germany have already taken steps to facilitate patent replacement by granting “compulsory licenses” for medicines, vaccines and other medical tools to Covid-19. Likewise, the Israeli government granted a compulsory license for patents on a drug they were investigating for use against the disease.

After intense criticism from civil society groups and MSF, the pharmaceutical corporation Gilead has just renounced a special designation from the United States Food and Drug Administration (FDA) that would allow prolonged monopoly control over 20 years of patents applied for in more than 70 countries for its potential candidate for Covid-19 treatment, remdesivir. Preliminary results from clinical trials using remdesivir to treat Covid-19 are expected in April. However, Gilead has not yet committed to not applying its patents globally.

MSF is deeply concerned about access to future drugs, tests and vaccines against the new coronavirus in places where MSF works and in other countries affected by this pandemic. The organization asks governments to prepare to suspend or replace Covid-19’s medical tool patents by issuing mandatory licenses. Removing patents and other barriers is critical to helping ensure that there are enough suppliers selling at prices everyone can afford.

American diagnostic test maker Cepheid offers another example of pandemic profit. The company has just received the US FDA Emergency Use Authorization for a rapid Covid-19 test (Xpert Xpress SARS-CoV-2) that provides results in just 45 minutes, using existing test machines that have been routinely used for tuberculosis, HIV and other diseases.

Cepheid has just announced that it will charge $ 19.80 per test in developing countries, including the poorest countries in the world, where people live on less than $ 2 a day. Research from MSF and other institutions on Cepheid’s tuberculosis test – which uses a similar tuberculosis test cartridge, for which the corporation charges $ 10 in developing countries – shows that the cost of products, including manufacturing, overhead and other expenses for each cartridge is $ 3, so each test can be sold at a profit for half the price: $ 5.

MSF warned that high prices and monopolies will result in the rationing of medicines, tests and vaccines, which will result in the prolongation of this pandemic.

News from: Paranashop

News

BPTO provides software registration manual in English and Spanish

BPTO has made available the Computer Program User Manual in Portuguese, English and Spanish versions. This is the first service of the Institute to have a trilingual manual.

With the manuals, BPTO intends to facilitate access to the internationally-registered software registration service in Brazil, valid in all member countries of the Berne Convention.

Access the manuals

E-Software system

Since 2017, the computer program registration process has been done completely online and with automated decisions through the e-Software system. After the implementation of the system, the certificate of registration became available on the BPTO Portal within 7 (seven) business days.
In recognition of this action, e-Software is one of the three finalists of the HDI ” Citizen IT Initiative 2019 ” award. The final contest will be on October 17th during EXPOGOV 2019.

News from: BPTO